The well-known generic armodafinil brand Artvigil 150 usually starts to operate one to two hours after consumption. As the drug achieves its optimum effectiveness in three to four hours, many users report increased mental alertness, attention, and cognitive energy. For people who require prolonged wakefulness, its effects can extend up to 12–14 hours.

How rapidly it works may depend on a number of factors, including metabolism, diet, and general health. Artvigil can increase alertness, but in order to prevent any negative effects or sleep disturbances, it should only be used under medical supervision.